How to configure Outlook 2010 to connect to an email account
Microsoft Outlook 2010 is a Windows email client that comes with Microsoft Office 2010.
You can create a new email account form the Email section of the Pixie control panel. If you don't know how to do it read the tutorial on creating an email account.
You can then add your email account in Outlook 2010. To do this, after you start Outlook go to File and click on Account Settings. On the window that pops out click on the button New. On the next window type your name, the full email address, the password for the email account, mark the button Manually configure server settings and click on Next. On the next window the button Internet E-mail should be marked by default; that's the one you need, so click on Next.
On the next window select either IMAP or POP3 from the Account Type drop-down menu. In the fields for incoming and outgoing mail server you can type just your domain name (e.g. yourdomain.com), as long as it points to our servers, or you can use the name or IP address of the HostKnox server hosting your account. You have to use the server name or IP address if you want to use encryption. On the same window you also have to type your full email address in the field for User Name and the password in the respective field. Then click on More Settings in the lower right corner of the window.
On the new window the opens click on the Outgoing Server tab and mark the checkbox My outgoing server (SMTP) requires authentication. After that click on the Advanced tab and if you want to use encryption set both of the drop-down menus that are there to SSL. You also have to change the port numbers for incoming and outgoing mail server to the following: 465 for outgoing (SMTP) with SSL; 587 for outgoing without SSL; 993 for incoming IMAP with SSL; 143 for IMAP without SSL; 995 for incoming POP3 with SSL; 110 for POP3 without SSL.
Once you've done everything click on OK. Then back on the previous window click on Next and on Finish.
For screenshots and some more details check out the tutorial on configuring Microsoft Outlook 2010 to connect to your email account.